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Esomeprazole Magnesium

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产品编号 T2686Cas号 161973-10-0
别名 埃索美拉唑镁, NEXIUM, (S)-Omeprazole magnesium, (-)-Omeprazole magnesium

Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。

Esomeprazole Magnesium

Esomeprazole Magnesium

Rating icon 很棒
纯度: 98.84%
产品编号 T2686 别名 埃索美拉唑镁, NEXIUM, (S)-Omeprazole magnesium, (-)-Omeprazole magnesiumCas号 161973-10-0

Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。

规格价格库存数量
25 mg¥ 287现货
50 mg¥ 410现货
100 mg¥ 565现货
200 mg¥ 828现货
1 mL x 10 mM (in DMSO)¥ 434现货
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纯度:98.84%
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产品介绍

生物活性
产品描述
Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
激酶实验
Purified enzyme assays: ATM for use in the in vitro assay is obtained from HeLa nuclear extract by immunoprecipitation with rabbit polyclonal antiserum raised to the COOH-terminal 400 amino acids of ATM in buffer containing 25 mM HEPES (pH 7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v glycerol, and 0.1% v/v Igepal. ATM-antibody complexes are isolated from nuclear extract by incubating with protein A-Sepharose beads for 1 hour and then through centrifugation to recover the beads. In the well of a 96-well plate, ATM-containing Sepharose beads are incubated with 1 μg of substrate glutathione S-transferase–p53N66 (NH2-terminal 66 amino acids of p53 fused to glutathione S-transferase) in ATM assay buffer [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, and 5% v/v glycerol] at 37 °C in the presence or absence of inhibitor. After 10 minutes with gentle shaking, ATP is added to a final concentration of 50 μM and the reaction continued at 37 °C for an additional 1 hour. The plate is centrifuged at 250 × g for 10 minutes (4 °C) to remove the ATM-containing beads, and the supernatant is removed and transferred to a white opaque 96-well plate and incubated at room temperature for 1.5 hours to allow glutathione S-transferase-p53N66 binding. This plate is then washed with PBS, blotted dry, and analyzed by a standard ELISA technique with a phospho-serine 15 p53 antibody. The detection of phosphorylated glutathione S-transferase-p53N66 substrate is performed in combination with a goat antimouse horseradish peroxidase-conjugated secondary antibody. Enhanced chemiluminescence solution is used to produce a signal and chemiluminescent detection is carried out.
别名埃索美拉唑镁, NEXIUM, (S)-Omeprazole magnesium, (-)-Omeprazole magnesium
化学信息
分子量713.12
分子式C34H36MgN6O6S2
CAS No.161973-10-0
SmilesC(S1=O[Mg+2]2([N]3=C(S(CC4=C(C)C(OC)=C(C)C=N4)=O2)[N-]C=5C3=CC=C(OC)C5)[N]6=C1[N-]C=7C6=CC=C(OC)C7)C8=C(C)C(OC)=C(C)C=N8
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
Ethanol: 143 mg/mL (200.52 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 45 mg/mL (63.1 mM)
溶液配制表
1mg5mg10mg50mg
1 mM1.4023 mL7.0114 mL14.0229 mL70.1144 mL
5 mM0.2805 mL1.4023 mL2.8046 mL14.0229 mL
10 mM0.1402 mL0.7011 mL1.4023 mL7.0114 mL
20 mM0.0701 mL0.3506 mL0.7011 mL3.5057 mL
50 mM0.0280 mL0.1402 mL0.2805 mL1.4023 mL
1mg5mg10mg50mg
100 mM0.0140 mL0.0701 mL0.1402 mL0.7011 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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